Does nicotine in cigarettes lead to a greater threat of schizophrenia?

in the press


this 1 latestThe nicotine in cigarette smoke may cause brain changes which actually increase the risk of developing schizophrenia by two-fold, a BBC report based on research from a team at Kings College London who reported in The Lancet Psychiatry. While the incidence of schizophrenia is 1 in 100, smoking may double the incidence to two in one hundred. This was a meta-study which analysed 61 published studies. Referring to this type of study, lead researcher Dr James McCabe stated “It’s very difficult to establish causation. What we’re hoping that this does is really open our eyes to the possibility that tobacco could be a causative agent in psychosis. This could then lead to other research and clinical trials that would help to provide firmer evidence.” Dr MacCabe works at Institute of Psychiatry, Psychology, and Neuroscience at King’s College London.
It’s already largely accepted in the research communities that people with psychosis are more prone to smoke and self medicating. 57% of people with psychosis were smokers prior to their first psychotic episode. Smokers developed schizophrenia a year earlier compared to non-smoking schizophrenics. This gives rise to the role nicotine may play in the causation of schizophrenia. This theory is further bolstered by the researchers’ determination that daily smokers were twice as likely to develop schizophrenia as their non-smoking counterparts.
The data indicates that the brain chemical alteration centres on dopamine changes. It has previously been established that nicotine alters dopamine. The causation theory this raises is based on the widely reported data that indicates nicotine impacts psychosis. The new research begs for more investigation to confirm or deny that in some people, perhaps those with an existing predisposition to schizophrenia, nicotine triggers a dopamine alteration leading to schizophrenia. Note that scientists are not suggesting that smoking alone causes schizophrenia. However, future findings may have further effect on public policy making. View full article


(10 July 2015) Does nicotine in cigarettes lead to a greater incidence of schizophrenia [editorial]. Retrieved from


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