Effect of e-cigarette use on Cough Reflex Sensitivity: Nicotine has a ‘dual-action’ according to study

in the press

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stateside thumbA new study from the American College of Chest Physicians found that the single use of an e-cigarette approximating the nicotine exposure of one tobacco cigarette reduces the sensitivity of the cough reflex. For the study, researchers collected and analysed data from 30 adult lifetime nonsmokers with no history of asthma or respiratory diseases and used cough tests to determine how e-cigarettes affect the cough reflex.
They used Capsaicin the pungent extract of red peppers, to induce a safe cough in the subjects and establish their baseline cough reflex sensitivity prior to use of an electronic cigarette. Each subject then inhaled 30 puffs of an electronic cigarette which contained nicotine in a vehicle of distilled water. 15 minutes after the e-cigarette vaping session, subjects were tested again and then tested again after 24 hours. Based on a comparison of results, a significant decrease in cough reflex sensitivity was shown within the subjects as compared with their baseline levels.
Researchers found that nicotine is probably responsible for the effect on the cough reflex. Previous studies have shown that nicotine also promotes cough immediately after ingestion, suggesting that nicotine has a dual action; an immediate stimulation of the cough reflex and a delayed inhibition. View full article
View findings CHEST: E-cigarette use on Cough Reflex Sensitivity

Dextromethorphan

University Herald (24 August 2015) E-Cigarette Use Linked To Cough Reflex Sensitivity [university editorial]. Retrieved from http://ow.ly/RgLZr

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